CD4 T Cell Responses in Latent and Chronic Viral Infections
نویسندگان
چکیده
منابع مشابه
CD4 T Cell Responses in Latent and Chronic Viral Infections
The spectrum of tasks which is fulfilled by CD4 T cells in the setting of viral infections is large, ranging from support of CD8 T cells and humoral immunity to exertion of direct antiviral effector functions. While our knowledge about the differentiation pathways, plasticity, and memory of CD4 T cell responses upon acute infections or immunizations has significantly increased during the past y...
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Infection with the AIDS virus has led to an expanding global health crisis, with over 45 million persons currently living with HIV infection. Ineffective immune control and resultant disease progression is a hallmark of this infection, despite the induction of vigorous virus-specific CD8 T cell responses in most infected persons. Although the features of protective immunity in HIV infection rem...
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CD8 T cell or cytotoxic T lymphocyte (CTL) responses are an important branch of the immune system in the fight against viral infections. The dynamics of anti-viral CTL responses have been characterized in some detail, both experimentally and with mathematical models. An interesting experimental observation concerns the timing of CTL responses. A recent study reported that in pneumonia virus of ...
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Background: The most common sexually transmitted diseases and the economic and social health problem throughout the world. However, vaccine coverage and antibiotic therapy and the development of programs to prevent and control major causes of acute and chronic diseases, pregnancy complications and infertility remains. Acute and chronic systemic viral infections can lead to infertility and perma...
متن کاملTGF-β receptor maintains CD4 T helper cell identity during chronic viral infections.
Suppression of CD8 and CD4 T cells is a hallmark in chronic viral infections, including hepatitis C and HIV. While multiple pathways are known to inhibit CD8 T cells, the host molecules that restrict CD4 T cell responses are less understood. Here, we used inducible and CD4 T cell-specific deletion of the gene encoding the TGF-β receptor during chronic lymphocytic choriomeningitis virus infectio...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2013
ISSN: 1664-3224
DOI: 10.3389/fimmu.2013.00105